• Period: Jul 2023 ~ Present

• Education

Mar 2021 ~ Feb 2025, B.S., Convergent Bioscience and Informatics, Chungnam National University

• Project

(1) Integrative Multi-omics Biomarker Discovery using Bioinformatic approaches

(2) Development of oncoprotein targeted therapy through molecular inhibition 

• Summary

I’m interested in understanding biological mechanisms and discovering biomarkers through proteome-centered multi-omics data analysis using bioinformatics approaches. My first project focuses on identifying early diagnostic biomarkers for high-risk pediatric patients through close collaboration with clinicians and experts in various omics fields. To achieve this, I’m learning analytical techniques such as Non-negative Matrix Factorization (NMF), Multi-Omics Factor Analysis (MOFA), statistical testing, and network-based approaches to investigate molecular interactions. My goal is to gain a systems-level understanding of biological mechanism using integrative bioinformatics methods. Also, I am interested in the design of oncoprotein-targeted inhibitors through molecular interaction. This involves identifying binding interfaces on target proteins via structural analysis of known drugs, followed by the design of peptide inhibitors using state-of-the-art deep learning models such as RFdiffusion, ProteinMPNN, and AlphaFold3. The goal of my second project is to computationally design peptide binders and experimentally validate their binding, ultimately proposing novel targeted therapeutics against oncoproteins.

• Publication

(1) Wonseok Lee*, Ahrum Son*, Jaeho Ji, Eunjeong Han, Ja-Young Cho, Ju-Won Kim, Young-Ok Kim, Hee Jeong Kong#, Hyunsoo Kim#. Elucidating Interactome Dynamics of the A2A Adenosine Receptor. Journal of Proteome Research (ISSN: 1535-3893) Accepted  (IF=3.8, Rank=17.6%) 

(2) Ahrum Son*, Jongham Park, Woojin Kim, Yoonki Yoon, Sangwoon Lee, Jaeho Ji, Hyunsoo Kim#. Recent Advances in Omics, Computational Models, and Advanced Screening Methods for Drug Safety and Efficacy. Toxins (EISSN: 2072-6651), 12 (11), 822 (11/14/2024) (IF=3.9, Rank=21.7%)

(3) Ahrum Son*, Jongham Park, Woojin Kim, Wonseok Lee, Yoonki Yoon, Jaeho Ji, Hyunsoo Kim#. Integrating Computational Design and Experimental Approaches for Next-Generation Biologics. Biomolecules (EISSN: 2218-273X), 14(9), 1073 (08/27/2024) (IF=4.8, Rank=21.4%)  

• Contact: kkdjaeho0612@gmail.com