• Period: Jun 2026 ~ Present

• Education

Mar 2025 ~ Present B.S., Department of Biological Sciences, Dankook University

• Project

(1) AI-Driven Design of AXL-Selective Peptide Inhibitors

• Summary

My project aims to develop AI-designed peptide inhibitors that selectively target AXL. AXL is a receptor

tyrosine kinase whose abnormal activation is associated with cancer progression, metastasis, immune

evasion, and therapeutic resistance. To identify promising peptide candidates, I perform structural analysis and interface hotspot identification using computational tools including PyMOL, Rosetta Flex ddG, and mCSM-PPI2. Based on these analyses, AI-based protein design methods such as RFdiffusion and ProteinMPNN are used to generate peptide candidates. The designed peptides are then computationally evaluated for their binding properties, selectivity toward AXL, and potential inhibitory activity, with the goal of developing selective peptide therapeutics targeting AXL signaling.

• Contact: lovenje0418@gmail.com