• Period: 2021.09 ~ 2025.03

• Education:

2021.09 ~ 2023.08 M.S., Department of Bio-AI Convergence, Graduate School, Chungnam National University

• Project:

(1)  Development of Targeted Mass Spectrometry-based Analysis Tool for Protein-Protein Interactions

(2)  Discovery of Structural Protein-Based Diagnostic Biomarkers in Alzheimer's Patients

• Summary:

I am currently engaged in two distinct projects: "Development of a Targeted Mass Spectrometry-Based Analysis Tool for Protein-Protein Interactions (PPIAT: Protein-Protein Interaction Analysis Tool)" and "Discovery of Structural Protein-Based Diagnostic Biomarkers in Alzheimer's Patients."

The primary focus of the PPIAT project revolves around the development of analytical capabilities necessary for the identification of physical protein-protein interactions using targeted mass spectrometry techniques. This entails tasks such as predicting interacting partner proteins with target proteins and automating the calculation of their monoisotopic mass values across various interaction scenarios. This research avenue is driven by a keen interest in advancing our understanding of protein interactions, with potential applications spanning multiple domains.

On the other front, the second project, "Discovery of Structural Protein-Based Diagnostic Biomarkers in Alzheimer's Patients," seeks to uncover specific protein interactions that are crucial in the context of Alzheimer's disease. The central aim here is to predict proteins that engage in physical interactions with APOE, a protein recognized as a significant risk factor in Alzheimer's pathology. By elucidating these interaction sites and patterns, the ultimate goal is to lay the foundation for the development of novel therapeutic interventions for Alzheimer's disease, grounded in a comprehensive understanding of protein structures and their implications.

In essence, my academic pursuits are deeply rooted in the exploration of disease biomarkers and the intricate landscape of structural interactions among proteins.

• Publication

(7) Ahrum Son*, Jongham Park, Woojin Kim, Yoonki Yoon, Sangwoon Lee, Jaeho Ji, Hyunsoo Kim#. Recent Advances in Omics, Computational Models, and Advanced Screening Methods for Drug Safety and Efficacy. Toxins (EISSN: 2072-6651), 12 (11), 822 (11/14/2024) (IF=3.9, Rank=21.7%) 

(6) Ahrum Son*, Jongham Park, Woojin Kim, Yoonki Yoon, Sangwoon Lee, Yongho Park, Hyunsoo Kim#. Revolutionizing Molecular Design for Innovative Therapeutic Applications through Artificial Intelligence. Molecules (EISSN: 1420-3049), 29(19), 4626 (09/29/2024) (IF=4.2, Rank=28.1%) 

(5) Ahrum Son*, Woojin Kim, Jongham Park, Yongho Park, Wonseok Lee, Sangwoon Lee, Hyunsoo Kim#. Mass Spectrometry Advancements and Applications for Biomarker Discovery, Diagnostic Innovations, and Personalized Medicine. International Journal of Molecular Sciences (ISSN: 1661-6596), 25(18), 9880 (09/12/2024) (IF=4.9, Rank=21.1%) 

(4) Ahrum Son*, Woojin Kim, Jongham Park, Wonseok Lee, Yerim Lee, Seongyun Choi, Hyunsoo Kim#. Utilizing Molecular Dynamics Simulations, Machine Learning, Cryo-EM, and NMR Spectroscopy to Predict and Validate Protein Dynamics. International Journal of Molecular Sciences (ISSN: 1661-6596), 25(17), 9725 (09/08/2024) (IF=4.9, Rank=21.1%) 

(3) Ahrum Son*, Jongham Park, Woojin Kim, Wonseok Lee, Yoonki Yoon, Jaeho Ji, Hyunsoo Kim#. Integrating Computational Design and Experimental Approaches for Next-Generation Biologics. Biomolecules (EISSN: 2218-273X), 14(9), 1073 (08/27/2024) (IF=4.8, Rank=21.4%)  

(2) Ahrum Son*, Woojin Kim, Wonseok Lee, Jongham Park, Hyunsoo Kim#. Applicability of Selected Reaction Monitoring for Precise Screening Tests. Expert Review of Proteomics (ISSN: 1478-9450), 21, 237-246 (05/08/2024) (IF=3.4, Rank=36.4%)  

(1) Jongham Park*, Ahrum Son*, Hyunsoo Kim#. A protein–protein interaction analysis tool for targeted cross-linking mass spectrometry. Scientific Reports (ISSN: 2045-2322), 13 (1), 22103 (12/13/2023) (IF=3.8, Rank=18.7%) 

• Patent

(1) 김현수, 박종함, 손아름. 타겟 질량분석법 기반의 단백질 상호작용체 분석 시스템 및 방법. 대한민국, 10-2022-0191149 (2022/12/30)

• Copyright

(1) 김현수, 박종함, 손아름. 표적 단백체 기반 단백질 상호작용체 분석 툴. 대한민국, C-2022-042073 (2022/10/31)

• Software

(1) 표적 단백체 기반 단백질 상호작용 분석 툴. 등록 번호: C-2022-042073 (2022/10/31)

     LINK: http://ppiat.cnu.ac.kr, https://github.com/kimlab-cnu/XL-MS_Analytics